{"id":231,"date":"2019-06-25T19:00:42","date_gmt":"2019-06-25T19:00:42","guid":{"rendered":"http:\/\/jaulinlab.com\/?page_id=231"},"modified":"2025-12-04T17:10:18","modified_gmt":"2025-12-04T17:10:18","slug":"research","status":"publish","type":"page","link":"https:\/\/jaulinlab.com\/fr\/research\/","title":{"rendered":"RECHERCHE"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"231\" class=\"elementor elementor-231\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c16d47e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c16d47e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e56efdb\" data-id=\"e56efdb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b08270c elementor-widget elementor-widget-spacer\" data-id=\"b08270c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c82c78d elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c82c78d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-452735e\" data-id=\"452735e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0268968 elementor-section-stretched elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"0268968\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f15dae7\" data-id=\"f15dae7\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c3da6b4 elementor-widget elementor-widget-text-editor\" data-id=\"c3da6b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Organo\u00efdes d\u00e9riv\u00e9s de patients pour des strat\u00e9gies de m\u00e9decine de pr\u00e9cision fonctionnelle<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f7d457 elementor-widget elementor-widget-text-editor\" data-id=\"4f7d457\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Malgr\u00e9 des avanc\u00e9es majeures, la m\u00e9decine de pr\u00e9cision bas\u00e9e sur la g\u00e9nomique et les th\u00e9rapies cibl\u00e9es ne b\u00e9n\u00e9ficie actuellement qu'\u00e0 7-10% des patients. Notre projet vise \u00e0 compl\u00e9ter ces approches mol\u00e9culaires par des approches de m\u00e9decine fonctionnelle personnalis\u00e9e (FPM), bas\u00e9es sur la r\u00e9ponse objective d'un test m\u00e9dicamenteux ex-vivo r\u00e9alis\u00e9 sur <strong>organo\u00efdes d\u00e9riv\u00e9s de patients (ODP)<\/strong><strong>)<\/strong> (=AVATAR DE TUMEUR). Effectu\u00e9 sur une base d'un patient, un test, ceci va <b><u>i<\/u>Identifier des m\u00e9dicaments efficaces contre la tumeur<\/b>, quel que soit son profil mol\u00e9culaire ou sa localisation anatomique, ainsi qu'\u00e0 mod\u00e9liser et anticiper la r\u00e9sistance au traitement. Depuis leur d\u00e9couverte il y a 10 ans, les organo\u00efdes sont devenus des outils puissants mais ne sont pas encore exploit\u00e9s en clinique en raison du manque de cohortes prospectives importantes abordant la validit\u00e9 et l'utilit\u00e9 cliniques de cette approche pour les cancers solides. \u00c0 l'interface entre l'INSERM et l'h\u00f4pital Gustave Roussy, le laboratoire Jaulin offre l'\u00e9cosyst\u00e8me id\u00e9al pour relever ce d\u00e9fi.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8d99f01 elementor-section-stretched elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"8d99f01\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-91c350c\" data-id=\"91c350c\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d72e22 elementor-widget elementor-widget-text-editor\" data-id=\"0d72e22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Notre objectif est de d\u00e9velopper <\/span><span style=\"text-decoration: underline;\"><strong>3 tests<\/strong><\/span> <span style=\"font-weight: 400;\">qui sera mis en \u0153uvre dans la clinique et contribuera \u00e0 g\u00e9n\u00e9rer de nouvelles connaissances \u00e0 partir de sp\u00e9cimens tumoraux de patients :\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a2b1b5 elementor-widget elementor-widget-text-editor\" data-id=\"2a2b1b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><span style=\"text-decoration: underline;\"><strong><strong>Le chemogramme<\/strong><\/strong><\/span><span style=\"font-weight: 400;\"> testeront la sensibilit\u00e9 de chaque organo\u00efde \u00e0 un large \u00e9ventail de m\u00e9dicaments (chimioth\u00e9rapies, th\u00e9rapies cibl\u00e9es) permettant de choisir le meilleur traitement et d'\u00e9viter les toxicit\u00e9s inutiles des traitements inefficaces.\u00a0<\/span><\/li><li><span style=\"text-decoration: underline;\"><strong>L'immunogramme<\/strong><\/span><span style=\"font-weight: 400;\"> pr\u00e9dira la r\u00e9ponse de chaque patient aux traitements d'immuno-oncologie, des inhibiteurs de points de contr\u00f4le immunitaires aux th\u00e9rapies cellulaires adoptives (CAR-T). <\/span><\/li><li><b><span style=\"text-decoration: underline;\">l'invagram<\/span><\/b><span style=\"font-weight: 400;\"> pr\u00e9dira l'agressivit\u00e9 (prolif\u00e9ration x invasion) des cancers afin de permettre une surveillance personnalis\u00e9e des patients \u00e0 risque de rechute<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c6cadce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c6cadce\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1a5d465\" data-id=\"1a5d465\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2ab6149 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2ab6149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-63c9dd8 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"63c9dd8\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2943c5f\" data-id=\"2943c5f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c0f7cb1 elementor-widget elementor-widget-text-editor\" data-id=\"c0f7cb1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>RHU ORGANOMIC<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d3389b elementor-section-stretched elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"2d3389b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-056da50\" data-id=\"056da50\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d61a95 elementor-widget elementor-widget-image\" data-id=\"0d61a95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"452\" height=\"373\" data-src=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/phenotypic-screening.webp\" class=\"attachment-large size-large wp-image-2070 lazyload\" alt=\"\" data-srcset=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/phenotypic-screening.webp 452w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/phenotypic-screening-300x248.png 300w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/phenotypic-screening-15x12.png 15w\" data-sizes=\"auto, (max-width: 452px) 100vw, 452px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 452px; --smush-placeholder-aspect-ratio: 452\/373;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7bcfee5\" data-id=\"7bcfee5\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf2dd1d elementor-widget elementor-widget-text-editor\" data-id=\"bf2dd1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Sur la base de nos travaux fondamentaux sur les PDO (Roy et al. 2017), ce programme de recherche \u201c du laboratoire \u00e0 la clinique \u201d a \u00e9t\u00e9 approuv\u00e9 et financ\u00e9 par un <\/span><a href=\"https:\/\/rhu-organomic.com\/\"><span style=\"text-decoration: underline;\"><strong>Subvention RHU (ORGANOMIC).<\/strong><\/span><\/a><span style=\"font-weight: 400;\"> Notre consortium de partenaires acad\u00e9miques et industriels a pour objectif de d\u00e9velopper des outils de diagnostic in vitro bas\u00e9s sur les PDO. Il combinera des technologies de pointe telles que l'intelligence artificielle, la mod\u00e9lisation math\u00e9matique, des approches bas\u00e9es sur la microscopie et la micro-ing\u00e9nierie pour g\u00e9n\u00e9rer des \u201c tumeurs sur puce \u201d destin\u00e9es \u00e0 standardiser et automatiser \u00e0 grande \u00e9chelle les tests r\u00e9alis\u00e9s sur des organo\u00efdes d\u00e9riv\u00e9s de chaque patient.\u00a0<\/span><\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1dc8571 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1dc8571\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eb40237\" data-id=\"eb40237\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a20812a elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a20812a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5073a36 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5073a36\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8fd6182\" data-id=\"8fd6182\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e8e8be6 elementor-widget elementor-widget-text-editor\" data-id=\"e8e8be6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>\u00c9tudes pr\u00e9cliniques : ORGANOPREDICT <\/b><\/p><h4><span style=\"font-weight: 400;\">\u201cMise en \u0153uvre clinique d'une strat\u00e9gie de m\u00e9decine personnalis\u00e9e bas\u00e9e sur des OP patients.<\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1e612d7 elementor-section-stretched elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"1e612d7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ff9eac2\" data-id=\"ff9eac2\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e968541 elementor-widget elementor-widget-text-editor\" data-id=\"e968541\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Pour les strat\u00e9gies FPM pour les patients, nous avons besoin<\/span><\/p><ul><li><span style=\"text-decoration: underline;\"><b>\u00c9volutivit\u00e9<\/b><\/span><span style=\"font-weight: 400;\"><span style=\"text-decoration: underline;\">:\u00a0<\/span> d\u00e9velopper la PDO chez la plupart des patients \u00e0 partir de minuscules biopsies d'aiguille (<\/span><b>taux de prise en charge<\/b><span style=\"font-weight: 400;\">),\u00a0<\/span><\/li><li><span style=\"text-decoration: underline;\"><b>Temporalit\u00e9<\/b><\/span><span style=\"font-weight: 400;\">afin de ne pas laisser les patients sans traitement, il a fallu pouvoir \u00e9tablir, amplifier et tester la pr\u00e9sence de drogues dans les OPF le plus rapidement possible (<\/span><b>d\u00e9lai de traitement<\/b><span style=\"font-weight: 400;\">),<\/span><\/li><li><span style=\"text-decoration: underline;\"><b>Pr\u00e9visibilit\u00e9<\/b><\/span><span style=\"font-weight: 400;\"><span style=\"text-decoration: underline;\">:<\/span> Il faut d\u00e9terminer la sensibilit\u00e9 et la sp\u00e9cificit\u00e9 des ch\u00e9mogrammes pour \u00e9valuer <\/span><b>leur valeur pr\u00e9dictive<\/b><span style=\"font-weight: 400;\">.Nos deux \u00e9tudes pilotes sur les cancers colorectal et pancr\u00e9atique, comprenant respectivement 40 et 81 patients, ont donn\u00e9 des r\u00e9sultats tr\u00e8s similaires. (voir publications: Cartry et al, 2023 J Clin Exp res; Boileve et al, Gastroenterology, 2024)<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/li><\/ul><p><span style=\"font-weight: 400;\">Nous avons g\u00e9n\u00e9r\u00e9 des organo\u00efdes pour 63% patients et produit le rapport ch\u00e9mogramme en <\/span><b>6,3 semaines<\/b><span style=\"font-weight: 400;\"> en moyenne pour un panel de <\/span><b>25 m\u00e9dicaments anticanc\u00e9reux<\/b><span style=\"font-weight: 400;\">. Notre essai pr\u00e9sente une sensibilit\u00e9 de 93%et une sp\u00e9cificit\u00e9 de 84%. De mani\u00e8re importante, pour 81% des patients, nous avons identifi\u00e9 au moins une mol\u00e9cule efficace et trois mol\u00e9cules efficaces en moyenne dans notre cohorte. Ces r\u00e9sultats et l'am\u00e9lioration de la technologie ont prouv\u00e9 que malgr\u00e9 les contraintes, la technologie des organo\u00efdes pourrait \u00eatre test\u00e9e dans un essai clinique interventionnel, \u00e0 condition que la biopsie soit r\u00e9alis\u00e9e au d\u00e9but de la derni\u00e8re ligne de traitement.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6b16c96\" data-id=\"6b16c96\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e49c25e elementor-widget elementor-widget-image\" data-id=\"e49c25e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"453\" height=\"399\" data-src=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/heart-1.jpg\" class=\"attachment-large size-large wp-image-2074 lazyload\" alt=\"\" data-srcset=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/heart-1.jpg 453w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/heart-1-300x264.jpg 300w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/heart-1-14x12.jpg 14w\" data-sizes=\"auto, (max-width: 453px) 100vw, 453px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 453px; --smush-placeholder-aspect-ratio: 453\/399;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ef73155 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ef73155\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-64d3d88\" data-id=\"64d3d88\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c14f3c9 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c14f3c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-80094bf elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"80094bf\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bf36ba9\" data-id=\"bf36ba9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d80655c elementor-widget elementor-widget-text-editor\" data-id=\"d80655c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">\u00c9tudes cliniques : <\/span><b>ORGANOTREAT <\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-78a7fa3 elementor-section-stretched elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"78a7fa3\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-770d200\" data-id=\"770d200\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f781752 elementor-widget elementor-widget-image\" data-id=\"f781752\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"390\" height=\"389\" data-src=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/tete-organoide.jpg\" class=\"attachment-large size-large wp-image-2075 lazyload\" alt=\"\" data-srcset=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/tete-organoide.jpg 390w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/tete-organoide-300x300.jpg 300w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/tete-organoide-150x150.jpg 150w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/11\/tete-organoide-12x12.jpg 12w\" data-sizes=\"auto, (max-width: 390px) 100vw, 390px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 390px; --smush-placeholder-aspect-ratio: 390\/389;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7592622\" data-id=\"7592622\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1736fe3 elementor-widget elementor-widget-text-editor\" data-id=\"1736fe3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Nous avons ouvert cet essai clinique en 2022. Couvrant toutes les tumeurs solides, il est le <\/span><b>premier essai clinique national de m\u00e9decine personnalis\u00e9e bas\u00e9 sur les PDOs<\/b><span style=\"font-weight: 400;\"> et l'une des premi\u00e8res \u00e0 l'\u00e9chelle internationale, nous permettant de prendre une position strat\u00e9gique dans le domaine. Il s'agit d'un essai acad\u00e9mique multicentrique interventionnel promu par Gustave Roussy visant \u00e0 d\u00e9terminer la faisabilit\u00e9 et l'efficacit\u00e9 de la m\u00e9decine personnalis\u00e9e fonctionnelle bas\u00e9e sur des organo\u00efdes.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\">Le premier segment de cet essai est une phase I\/II intitul\u00e9e <\/span><b>ORGANOTREAT-01<\/b><span style=\"font-weight: 400;\">, qui vise \u00e0 tester la faisabilit\u00e9 et l'efficacit\u00e9 d'un test m\u00e9dicamenteux personnalis\u00e9 r\u00e9alis\u00e9 \u00e0 partir d'organo\u00efdes d\u00e9riv\u00e9s de 60 patients atteints de cancer colorectal, vient de s'achever. Notre objectif principal est d\u00e9j\u00e0 positif puisque nous avons g\u00e9n\u00e9r\u00e9 des ch\u00e9mo-grammes pour 81% patients et effectu\u00e9 le test en 6,1 semaines.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c51fe72 elementor-section-stretched elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"c51fe72\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-592ac43\" data-id=\"592ac43\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-af28e06 elementor-widget elementor-widget-text-editor\" data-id=\"af28e06\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"font-size: 18px; font-weight: 400;\">Nos objectifs secondaires sont d'\u00e9valuer\u00a0<\/span>\n<ul>\n \t<li><span style=\"font-weight: 400;\">La proportion de patients effectivement trait\u00e9s conform\u00e9ment aux recommandations de la CTB et,<\/span><\/li>\n \t<li><span style=\"font-weight: 400;\">La r\u00e9ponse tumorale au traitement bas\u00e9e sur leur ch\u00e9mogramme (mesure de l\u201c\u00ab indice de modulation de la croissance \u00bb ou GMI (correspondant au rapport des survies sans progression avec la pr\u00e9c\u00e9dente ligne de traitement (PFS2\/PFS1)), ces donn\u00e9es sont actuellement collect\u00e9es.<\/span><\/li>\n<\/ul>\n<span style=\"font-weight: 400;\">Si elles s'av\u00e8rent concluantes, ces approches pourraient conduire \u00e0 un changement de paradigme dans la prise en charge des patients atteints de cancer. C'est en combinant des strat\u00e9gies de m\u00e9decine personnalis\u00e9e, bas\u00e9es sur la caract\u00e9risation du g\u00e9nome et des tests fonctionnels r\u00e9alis\u00e9s sur des avatars biologiques tels que les organo\u00efdes, que nous renforcerons notre arsenal m\u00e9dical face au cancer, cette maladie profond\u00e9ment h\u00e9t\u00e9rog\u00e8ne et complexe.<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6df244 elementor-widget elementor-widget-image\" data-id=\"d6df244\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"768\" height=\"483\" data-src=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/09\/Organotreat-768x483.webp\" class=\"attachment-medium_large size-medium_large wp-image-1903 lazyload\" alt=\"\" data-srcset=\"https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/09\/Organotreat-768x483.webp 768w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/09\/Organotreat-300x189.webp 300w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/09\/Organotreat-18x12.webp 18w, https:\/\/jaulinlab.com\/wp-content\/uploads\/2025\/09\/Organotreat.webp 912w\" data-sizes=\"auto, (max-width: 768px) 100vw, 768px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 768px; --smush-placeholder-aspect-ratio: 768\/483;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-452b5c0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"452b5c0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ca250ff\" data-id=\"ca250ff\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Patient-Derived Organoids for functional precision medicine strategies Despite major advances, precision medicine based on genomics and targeted therapies currently benefits only 7-10% of patients. Our project aims to complement these molecular approaches with functional personalized medicine (FPM) approaches, based on the objective response of an ex-vivo drug test performed on patient-derived organoids (PDOs) (=TUMOR AVATAR). [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"nf_dc_page":"","ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"on","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","footnotes":""},"class_list":["post-231","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/pages\/231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/comments?post=231"}],"version-history":[{"count":5,"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/pages\/231\/revisions"}],"predecessor-version":[{"id":2157,"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/pages\/231\/revisions\/2157"}],"wp:attachment":[{"href":"https:\/\/jaulinlab.com\/fr\/wp-json\/wp\/v2\/media?parent=231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}