Fanny Jaulin Chercheur Responsable

Fanny Jaulin, Ph.D

Group Leader

I have always been fascinated by cell shape, multicellular architecture and how this relates to tissue function. I did my PhD studies in the lab of Jean-Paul Borg working on protein complexes setting–up apico-basolateral polarity in normal epithelial tissues. As a postdoctoral fellow in New York, I trained in the labs of Geri Kreitzer (Weill Medical College) and Alan Hall (MSKCC) developping 3D cell biology and microscopy-based approaches to decrypt the role of the cytoskeleton in the morphogenesis of epithelial cells.

It is through the INSERM/CNRS ATIP-AVENIR award for young investigators that I have established my lab at the Gustave Roussy Institute. I now coordinate a team of talented scientists and clinicians to unlock some of the mysteries behind the metastatic progression of digestive cancers.

List of Publications

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Joël Raingeaud, Ph.D

Senior scientist

After ma graduation, from University of Limoges, I spent several years of postdoc at the UMass Medical Center (Worcester, Ma) working on the p38MAPK pathway then obtained a tenure track position at the CNRS, assigned to the Institut Curie. Then I focused my research on the molecular mechanisms underlying colorectal cancer cell dissemination and joined Fanny Jaulin’s team to investigate the budding process as an intermediate of the mucinous CRC collective dissemination.

List of Publications

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Jérôme Cartry, Ph.D

Engineer

I graduated with a Developmental Biology PhD in Paris VI (Jussieu) University in 2008. I, then joined the Sanford Burnham Prebys Medical Discovery Institute à San Diego (USA) to study cardiac function genetic. I have been working in Gustave Roussy since 2015, first as clinical research associate and now as an engineer in Jaulin’s lab. I develop a translational research approach aiming at using the organoid technology to propose personalized cancer therapy to patients.

List of Publications

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Michel Ducreux, MD, PhD

Head of the Gastrointestinal Oncology Unit

I am the head of the Gastrointestinal Oncology Unit at Gustave Roussy, and professor of oncology at University of Paris Saclay in France. I trained in medicine, gastroenterology, and gastrointestinal tract oncology at the University of Paris Sud, and hold a masters degree in biological sciences and a PhD in health sciences. I have held positions as assistant physician and professor of oncology at the Gastrointestinal Unit of Gustave Roussy and Paul Brousse Hospital in Villejuif. I was medical affairs director of Gustave Roussy from January 2011 to December 2019. I am the former chair of the European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group, and is the former chair of the Gastrointestinal Group of the French Federation of Anticancer Centers (FNCLCC). I am co-editor for GI oncology of the European Journal of Cancer.

List of Publications

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David Malka, MD, PhD

Gastrointestinal Tumor Group

Before joining Gustave Roussy in 2003, I was associate professor in the Department of Medical Oncology at Paul Brousse University Hospital (Villejuif, France; 2001-02), and formerly in the Department of Internal Medicine at Lariboisière University Hospital (Paris, France; 2000-01) and in the Department of Gastroenterology at Beaujon University Hospital (Clichy, France; 1998-2000). I earned an M.D., a certification in Hepatology and Gastroenterology, a Master degree in Biostatistics, Genetics and Molecular Biology, and a Ph.D. in Biological Sciences from the University of Paris. I am the past-president of the Gastrointestinal Group of UNICANCER, the French federation of comprehensive cancer centers.

List of Publications

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Maximiliano Gelli, MD

Chief of Surgical Oncology Unit

After completing my fellowship in HPB and Transplant surgery, I joined Gustave Roussy in 2016 to complete my training in surgical oncology. I am actually Chief of Surgical Oncology Unit and in charge to develop innovative treatments for digestive tract cancers and hepatobiliopancreatic robotic surgery. My topics of interest are primary (hepatocellular carcinoma and cholangiocarcinoma) liver tumors and metastatic colorectal cancer. I have always been interested by the multidisciplinary oncological approach of liver tumors in order to improve patients’ outcomes. In this setting, I’m actually carrying on my PhD in the lab of Fanny Jaulin focused on dissemination of colorectal cancer.

List of Publications

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Emmanuel Dornier, Ph.D

Senior post-doctoral fellow

I did my PhD in Eric Rubinstein’s lab at Hopital Paul Brousse (André Lwoff Institute, Villejuif) describing how membrane compartmentalization regulates ADAM10 metalloprotease and the Notch pathway activation. I then joined Jim Norman’s lab in Glasgow for my postdoc to study the role of vesicular trafficking in murine models of breast and pancreatic cancer. There I also developed an original project investigating how metabolism can fuel cancer invasiveness. In Fanny Jaulin’s team, I study the molecular mechanisms underlying a new mode of collective invasion discovered in the lab, as well as how metabolism could foster invasiveness of colorectal cancers.

List of Publications

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Diane-Laure Pagès, Ph.D
Scientist

I am an engineer, graduated from Ecole Polytechnique (France), and I did my Master 2 at Ecole Normale Supérieure (France) in the program Interdisciplinary Master in Life Sciences. I received my PhD in oncology (Philanthropia Foundation) in May 2022. 

My PhD project aimed at understanding the physical and molecular mechanisms that drive the collective migration of clusters from colorectal tumours (cell lines or Patients’ Derived Xenografts). They display a mode of migration that has never been described to date, independent from adhesion to the substrate. In collaboration with Piel’s lab (Curie Institute, Paris, France), I studied their migration in microchannels with long timelapse bright field and fluorescence microscopy. These tools allowed me to observe their behavior while interfering with actin contractility and polymerization.

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Jean-Baptiste Lopez

Ph.D Student

I am a PhD student financed by the FRM (Fondation pour le Recherche Médicale). I did my master’s degree in Cancer Genetics and Epigenetics at Paris VI University (Jussieu-Pierre et Marie Curie).

My PhD project is about understanding how TSIPs found in patients are formed and emerge from the primary tumor. We know that in our studies the TSIPs do not form by aggregation and emerge collectively from serrated precursors of the cancerous epithelium in a specific molecular context. To understand the cellular events and the molecular signature associated with the formation of TSIPs we are trying to recapitulate the phenomenon in vitro mainly with cell lines in culture.

List of Publications

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Aurore Maciejewski

Ph.D Student

I studied for 3 years in the medical University of Tours before graduating from University of Paris Saclay with a master’s degree in cell biology and genetics of cancer. Being part of the “Ecole de l’Inserm” MD-PhD program, I started my thesis in the Jaulin lab, planning on finishing my medical studies after that.

My PhD project aims at studying the concept of collective migration plasticity, through which clusters can adopt various migration mode to adapt to the environment they move into. I am also interested in the role of cytoskeleton and cell-cell junctions in the coordination and cohesiveness of clusters adopting various collective migration modes.

List of Publications

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Jacques Mathieu, Ph.D

Project CoorDinator

I obtained a doctorate in oncology at the University of Paris-Saclay (formerly Paris XI) in the team of Florence Cabon (André Lwoff Institute, Villejuif). My thesis focused on two key angiogenesis proteins, VEGFA and TSP1, in prostate cancer. I then joined the team of Carole Peyssonnaux at the Cochin Institute to study the role of hepcidin in intestinal physiopathology and in breast carcinogenesis. In the Jaulin’s laboratory, I coordinate the research projects.

List of Publications

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Clemence Nguyen-Vigouroux

postdoctoral researcher

During my PhD in Christophe Le Clainche’ lab, I studied the mechanosensitivity of extracellular matrix adhesions and their link to the actomyosin cytoskeleton at the molecular level through reconstituted assays. 

To complement my biochemistry background, I then joined Fanny Jaulin’s team as a postdoctoral researcher to explore the mechanisms of collective plasticity. The aim of my project is to unveil the cellular and molecular cues allowing cell clusters to adapt their mode of migration depending on their environment, and in particular the role of adhesion and contractility in collective plasticity.

List of Publications

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Alice Boilève, MD

Ph.D Student

Currently a doctoral student in the PhD program in oncology (Fondation Philanthropia), I am a physician, specializing in medical oncology, and particularly in digestive cancers. As a graduate of the École Normale Supérieure (France) in biology, I joined the medical curriculum in 2012. I joined the Jaulin’s lab at the end of my internship, in 2021.

My doctoral project aims to elucidate the mechanisms of pancreatic cancer invasion. By analogy to the program involved in the metastatic dissemination of colorectal cancers via TSIPs, we wish to determine if such a program could also be activated in pancreatic cancers and if TSIPs are tumor intermediates in these cancers. I will use organoids from healthy pancreas and tumors as a model.

In parallel with this project, I coordinate with the digestive committee and Fanny Jaulin’s laboratory the ORGANOTREAT-02P trial, a translational and clinical research program that will generate organoids from pancreatic tumors, in order to be able to offer the patient a personalized treatment, according to the response of organoids to different chemotherapy molecules.

List of Publications

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Sabrina Bedja
engineer

I obtained my bachelor’s degree in Cellular biology and Physiology at the University of Reims Champagne-Ardenne, France in 2017. Then, I moved to Paris to start a master’s degree in Biology and Experimental therapies at the University of Paris 13, France, which i obtained in July 2019. After that, i moved to Montpellier to work with Morris’s team on kinase dysregulation and CDK4 inhibitors in cancer.
During my master’s degree, i did two internships in U1152 ”Physiopathology and epidemiology in lung diseases” in Pretolani’s team under supervision of Dr Séverine Létuvé.  I developed strong skills in cellular biology, molecular biology, histology and culture cell because i had the opportunity to work with human bronchial epithelial cells, obtained by extraction from pulmonary biopsies and bronchia.
In 2019, i presented a communication on my work at the Lungstorming meeting, organized by GSK in Nans-les-Pains. I started to work at Jaulin’s lab in September 2020. I work on a project with specific cellular structure: organoids. With that, we tried to develop personalize treatment for patient.

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Emilie Gontran
ENGINEER

With a background at the interface Physics-Biology, I specialized in the development and the characterization of three-dimensional (3D) cell systems to meet challenges in physiopathogenesis contexts such as brain tumor growth, embryogenesis defects observed in ciliopathies and tubular epithelial cell models during my PhD and my postdoc. In Fanny Jaulin’s team, I develop analytical tools and scientific projects in the context of 3D collective cell migration involved in metastasis formation and cancer organoid-related studies to better predict colorectal cancer progression.

List of Publications

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Nicolas Pasquier

PH.D STUDENT

I am PhD student in the “PhD in Oncology” programme (Philanthropia Foundation). I graduated as an engineer in 2019 from the ESPCI Paris (France) and I did a Masters at the Centre de Recherche Interdisciplinaire (CRI – University of Paris) in Life Science.

My PhD project, led both in the Jaulin Lab as well as the Ivaska Lab at the University of Turku (Finland) aims at deciphering the oncogenic parameters that determine the TSIPs polarity, focusing mainly on the Focal Adhesion pathway. I am also studying the impact of the physico-chemical properties of the matrix on their polarity and architecture, and how it can impact their metastatic potential in vivo.

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FORMER LAB MEMBERS

PhD Students:

Charlotte Canet-Jourdan

PhD student, 2017-2022 – List of Publications